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Changes in systolic time intervals—a non‐invasive marker for the haemodynamic effects of sumatriptan
Author(s) -
Hood Stuart,
Birnie David,
Murray Lilian S.,
MacIntyre Paul D.,
Hillis W. Stewart
Publication year - 1999
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1999.00121.x
Subject(s) - sumatriptan , medicine , afterload , hemodynamics , cardiology , anesthesia , cardiac catheterization , blood pressure , ejection fraction , placebo , systole , agonist , diastole , heart failure , receptor , alternative medicine , pathology
Aims This study assessed the use of systolic time intervals (STI) as a potential non‐invasive marker of the haemodynamic effects of sumatriptan, a 5HT 1 receptor agonist.Methods Twenty‐six patients undergoing diagnostic cardiac catheterization participated. STIs were derived from haemodynamic pressure tracings at baseline, following placebo injection and following either subcutaneous (n=18) or intravenous injection (n =8) of sumatriptan.Results Sumatriptan (i.v. or s.c.) was associated with significant increases in mean arterial pressure (95% C.I. 9,14mmHg, P=0.0001), total electromechanical systole (95% C.I.8,36ms, P<0.0001), pre‐ejection period (95%C.I. 8,21ms, P=0.0001) and left ventricular ejection time (95% C.I. 2,12ms, P =0.004).Conclusion STI responses were consistent with sumatriptan‐induced changes in afterload. In summary, the measurement of STIs is a potential non‐invasive method of investigating the influence of serotonergic compounds on the cardiovascular system.