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Pharmacokinetics of rifabutin in HIV‐infected patients with or without wasting syndrome
Author(s) -
Gatti,
Antonio Di Biagio,
D. De Pascalis,
Guerra,
Bassetti
Publication year - 1999
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1999.00069.x
Subject(s) - rifabutin , wasting syndrome , pharmacokinetics , wasting , medicine , gastroenterology , human immunodeficiency virus (hiv) , immunology , clarithromycin , helicobacter pylori
Aims The purpose of the study was to compare the pharmacokinetic parameters of rifabutin obtained in a group of patients without wasting syndrome (NWS) with those obtained in a group with wasting syndrome (WS).Methods A single dose of 300 mg rifabutin was administered in the fasting state to the patients in both study groups and blood samples were scheduled to be collected at the following times: 0 (predose), 0.5, 1, 2, 3, 4, 6, 8, 24, 48, 72 and 96 h following administration. Data were analysed using noncompartmental methods. The pharmacokinetic parameters of rifabutin in patients with and without wasting syndrome were compared using the Mann–Whitney U ‐test.ResultsC max was 0.34±0.14 mg l −1 in NWS patients and 0.55±0.16 mg l −1 (P=0.01) in patients with WS. t max was 4.2±1.5 and 3.3±2.3 h (P=0.17) in NWS and WS patients, respectively. The AUCs were similar in the two study groups. V/F was 2905±1646 l in NWS patients and 1701±492 l (P=0.07) for the WS group. These differences are less pronounced following normalization of V/F to patients body weight (43.7±20.1 vs 35.4±10.3 l kg −1 ). t 1/2,λz tended to be shorter in patients with WS (31.4±12.9 vs 46.0±23.5 h, P =0.12).Conclusions Our study suggests that the pharmacokinetics of rifabutin in patients with wasting syndrome are not altered to a degree that is clinically important.