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Persistence of anti‐hypertensive effect after missed dose of perindopril
Author(s) -
Kcb Tan,
Frans H. H. Leenen
Publication year - 1999
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1999.00055.x
Subject(s) - perindopril , persistence (discontinuity) , medicine , pharmacology , blood pressure , geotechnical engineering , engineering
Aims To assess the persistence of the antihypertensive effect of the ACE‐inhibitor perindopril after one missed dose.Methods After a placebo run‐in period, 10 hypertensive patients were started on perindopril 4 mg once daily in the morning, increased to 8 mg once daily after 4 weeks if office diastolic BP >85 mmHg. 24 h BP monitoring was performed at the end of the placebo run‐in period and during active treatment in week 9 and 10 on either active treatment or a placebo‐day using a double‐blind, randomized, cross‐over design.Results Office BP decreased from 155±3/100±2 mmHg at the end of placebo to 139±3/89±2 mmHg (P<0.05 vs placebo) after 8 weeks of active treatment. After 2 months of active treatment, 24 h ABP showed significant decreases in day BP by −11±1/−7±1 mmHg and in night BP by −11±2/−7±1 mmHg while on active treatment. During the placebo‐day, daytime BP showed decreases by −10±1/−5±1 and night BP by −8±2/−6±1 mmHg (NS vs active treatment day).Conclusions Perindopril 4–8 mg day −1 causes a persistent decrease in BP during the 24 h dosing interval, which is mostly maintained over the 24–48 h after dosing.