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Pharmacokinetic and pharmacodynamic drug interactions between digoxin and macrogol 4000, a laxative polymer, in healthy volunteers
Author(s) -
Ragueneau Isabelle,
Poirier JeanMarie,
Radembino Nathalie,
Sao Anne Buu,
FunckBrentano Christian,
Jaillon Patrice
Publication year - 1999
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1999.00025.x
Subject(s) - digoxin , pharmacokinetics , medicine , pharmacology , cmax , pharmacodynamics , drug interaction , oral administration , laxative , bioavailability , heart rate , therapeutic index , bioequivalence , drug , heart failure , blood pressure , constipation
Aims The aim of this study was to examine the bioequivalence between a single oral dose of digoxin administered alone and with a coadministration of macrogol 4000 (a laxative polymer) in 18 healthy volunteers.Methods This was an open, randomised, two‐way cross‐over study, with a single dose oral administration of 0.5 mg digoxin administered alone or in combination with macrogol 4000, 20 g day −1 during 8 days. Pharmacokinetics of digoxin, heart rate and PR ECG interval at rest were assessed.Results Macrogol 4000 coadministration was associated with a 30% decrease of digoxin AUC and a 40% decrease in its C max (P<0.05). Digoxin t max and t 1/2,z were not significantly altered. Heart rate and PR interval did not differ during the two therapeutic sequences, digoxin alone and digoxin in combination.Conclusions Macrogol 4000 coadministration interacts with single‐dose digoxin pharmacokinetics. This is most likely due to a reduction of the intestinal absorption of digoxin. However, there was no consequence of this interaction on heart rate and AV conduction.