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The effects of age and gender on the pharmacokinetics of irbesartan
Author(s) -
Vachharajani Nimish N.,
Shyu Wen Chyi,
Smith Robert A.,
Greene Douglas S.
Publication year - 1998
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1998.00837.x
Subject(s) - irbesartan , pharmacokinetics , medicine , urine , endocrinology , area under the curve , angiotensin ii receptor antagonist , angiotensin ii , urology , losartan , blood pressure
Aims Single dose pharmacokinetics and safety of irbesartan, an angiotensin II receptor antagonist, were evaluated in healthy young and elderly male and female subjects.Methods Irbesartan was administered as two 25 mg capsules after a 10 h fast to 12 young men, 12 young women, 12 elderly men and 12 elderly women. Serial blood and urine sample were collected up to 96 h after the dose. Plasma and urine samples were analysed for irbesartan by h.p.l.c./fluorescence methods.Results No statistically significant gender effects were observed in peak plasma concentration (C max ), area under the curve (AUC), and terminal elimination half‐life (t 1/2 ) of irbesartan. The geometric mean AUC and C max increased by about 43% and 49%, respectively, in the elderly subjects. Also the time to peak was significantly shorter in the elderly subjects compared with that observed in the young subjects. Renal clearance of irbesartan was significantly reduced in the elderly females but this reduction is not likely to be of any clinical relevance since less than 3% of the administered dose of irbesartan is excreted unchanged in the urine.Conclusions Although there was an effect of age on the pharmacokinetics of irbesartan, based on the safety and efficacy profile, no adjustment in irbesartan dosage is necessary with respect to age or gender.