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Paracetamol metabolism in patients with ulcerative colitis
Author(s) -
Kent V. Haderslev,
Jesper Sonne,
Henrik E. Poulsen,
Steffen Loft
Publication year - 1998
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1998.00808.x
Subject(s) - ulcerative colitis , pharmacokinetics , urine , medicine , glucuronide , gastroenterology , urinary system , acetaminophen , oral administration , analgesic , pharmacology , colitis , chemistry , disease
Aims The capacity for sulphation of phenols appears to be impaired in the colonic mucosa of patients with ulcerative colitis. The aim of the present study was to investigate the systemic capacity for sulphation of phenols in patients with ulcerative colitis assessed by the metabolic clearances of paracetamol to the sulphate, glucuronide and glutathione derived metabolites.Methods Ten patients with ulcerative colitis and 10 control subjects received a single oral dose of paracetamol (1 g). Venous blood samples were collected frequently for pharmacokinetic determinations (one compartment model). Urine was collected for 24 h. Plasma samples were analysed for parent drug and urine samples for parent drug and metabolites by h.p.l.c. Partial metabolic clearances were calculated as the fractional urinary recovery of each conjugate multiplied by the apparent oral clearance of paracetamol.Results The apparent oral clearance of paracetamol and the partial clearances of its metabolites were not significantly different between the two study groups. Median value and the corresponding 25th and 75th percentiles for the clearance of the sulphate metabolites were 93.6 (82.5–138.8) ml kg −1 h −1 and 77.4 (75.5–99.1), patients with ulcerative colitis and control subjects, respectively.Conclusions These results do not indicate a general impairment of the systemic capacity for sulphation of paracetamol in patients with ulcerative colitis.