Premium
Lacidipine: effects on vascular pressor responses throughout the dosage interval in normotensive subjects
Author(s) -
Ueda Shinichiro,
Donnelly Richard,
Panfilov Vsevolod,
Morris Andrew D.,
Elliott Henry L.
Publication year - 1998
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1998.00760.x
Subject(s) - lacidipine , medicine , antagonist , dihydropyridine , placebo , crossover study , angiotensin ii , pharmacology , endocrinology , anesthesia , blood pressure , calcium , receptor , alternative medicine , pathology
Aims To assess the duration and consistency of the pharmacological activity of the dihydropyridine calcium antagonist drug, lacidipine.Methods Eight healthy normotensive young males participated in a double‐blind randomised crossover comparison of single and multiple doses (for 2 weeks) of lacidipine and placebo. The calcium antagonist effects were quantified at 2, 6 and 24 h post dose by the extent of the attenuation of the pressor responses to the intravenous administration of the vasoconstrictors angiotensin II and noradrenaline.Results After 2 weeks of treatment, lacidipine consistently and significantly attenuated the pressor responses to both agents at 2 h post dose. At 6 and 24 h post dose there was a significant and progressive decline in the effectiveness of lacidipine in attenuating the pressor responses and for the response to angiotensin II there was no statistically significant effect at either 6 or 24 h post dose.Conclusions These results indicate that there is an obvious ‘peak’ in the pharmacological activity of lacidipine at about 2 h post dose and that this activity is not fully and consistently maintained throughout 24 h.