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Computerized surveillance of adverse drug reactions in hospital: pilot study
Author(s) -
AzazLivshits Tatyana,
Levy Micha,
Sadan Batami,
Shalit Meir,
Geisslinger Gerd,
Brune Kay
Publication year - 1998
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1998.00685.x
Subject(s) - medicine , drug reaction , retrospective cohort study , observational study , emergency medicine , adverse drug reaction , adverse effect , medical record , drug , pediatrics , pharmacology
Aims To develop and assess the use of computerized laboratory data as a detection support tool of adverse drug reactions (ADRs) in hospital.Methods This was a retrospective observational study of 153 sequential medical admissions during a 2‐month period to the 34‐bed medical ward at the Hadassah University Hospital, Jerusalem, Israel. Measurements made were 1) Retrospective chart review for recognized and unrecognized adverse drug reactions (ADRs) and 2) Analysis of computerized laboratory data according to defined automatic laboratory signals (ALS) for adverse reactions.Results Forty ADRs have been detected in 38 out of the 153 hospital admissions (24.8%). Nine reactions were considered severe. Altogether 212 ALS were generated involving 86 admissions. In 25 (65.8%) of the ADR‐positive admissions ADRs were detected through automatic signals generated from the laboratory data. ALS were detected in 56 out of the 115 (48.7%) ADR‐negative admissions. Twenty‐four (60%) of the ADRs were not recognized as such by the attending physicians. Two of these reactions were severe. ALS could have generated an alert for 19 (79.2%) of the unrecognized reactions.Conclusions Application of automatic laboratory signals can increase the rate of recognition of ADRs and thereby improve medical care. The sensitivity and specificity of the method might be increased by refinement and redefinition of the signals.