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Pharmacokinetics of digoxin‐specific Fab: effects of decreased renal function and age
Author(s) -
Renard C.,
GreneLerouge N.,
Beau N.,
Baud F.,
Scherrmann J. M.
Publication year - 1997
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1997.00654.x
Subject(s) - pharmacokinetics , renal function , digoxin , volume of distribution , creatinine , digitoxin , radioimmunoassay , plasma clearance , medicine , distribution (mathematics) , urology , endocrinology , chemistry , heart failure , mathematical analysis , mathematics
Aims To study the influence of age and renal function on digoxin‐specific Fab (DS‐Fab) pharmacokinetics. Methods Sixteen patients (35–91 years) with creatinine clearance ranging from 10.6 to 122.1 ml min −1 who had been admitted to hospital with severe digoxin or digitoxin self‐poisoning were treated with DS‐Fab (80 to 800 mg). Plasma DS‐Fab concentrations were determined by radioimmunoassay. Results The mean (±s.d.) distribution and elimination half‐lives, apparent volume of distribution and total body clearance were 1.1±0.4 h, 20.2±7.3 h, 13.1±5.8 l, and 17.6±10.8 ml min −1 , respectively. Interindividual variability of DS‐Fab total body clearance was linked linearly with the decrease in creatinine clearance or with the increase in age and DS‐Fab distribution volume was not dependent on creatinine clearance or age. Conclusions The data suggest that DS‐Fab should be given to elderly and renal‐impaired patients at doses similar to those given to younger or normal renal function patients.