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Lack of pharmacokinetic interaction between butorphanol nasal spray and cimetidine
Author(s) -
SHYU W. C.,
BARBHAIYA R. H.
Publication year - 1996
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1996.4592.x
Subject(s) - cimetidine , pharmacokinetics , butorphanol , medicine , nasal spray , pharmacology , pharmacokinetic interaction , anesthesia , drug interaction , nasal administration
The potential for a pharmacokinetic interaction between butorphanol nasal spray and cimetidine, under steady state conditions, was evaluated in 16 healthy male volunteers. Subjects received either a 1 mg butorphanol nasal spray every 6 h or a 300 mg cimetidine tablet every 6 h on days 1–4, the combination of two compounds every 6 h on days 5–8 and the original treatment as described in the first segment (days 1–4) on days 9–12. Serial blood and urine samples were collected on days 4, 8 and 12, and additional blood samples were taken immediately, prior to the morning dose on days 3, 7 and 11. Based on the analysis of the C min samples, the plasma concentrations of cimetidine and butorphanol achieved steady state by the third day of dosing. No statistically significant differences were found in the plasma concentrations of butorphanol or cimetidine (except for t ½ and MRT) between any of the treatment phases. Butorphanol nasal spray and cimetidine can be co‐administered without any adjustment of dosage for either drug.