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Effect of locally applied prazosin on the kinetics of the pupillary light reflex
Author(s) -
MORTLOCK S.A.,
LANGLEY R. W.,
BRADSHAW C. M.,
SZABADI E.
Publication year - 1996
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1996.39715.x
Subject(s) - prazosin , pupillary light reflex , phenylephrine , medicine , reflex , pupil , pupillometry , anesthesia , stimulation , antagonist , neuroscience , psychology , blood pressure , receptor
The effect of locally applied prazosin on pupillometric measures was studied in healthy volunteers, in an attempt to identify the role of α 1 ‐adrenoceptors in the recovery time of the light reflex. Prazosin antagonized the mydriatic effect of phenylephrine, but did not alter that of tropicamide. Miotic responses to a range of light stimuli were measured under ambient temperature conditions of 22° C and 40° C. The 40° C condition was associated with shorter recovery times of the light reflex; prazosin increased the recovery time under both temperature conditions. Response amplitude was not affected by the temperature condition or prazosin. The results are consistent with the hypothesis that sympathetic neuromuscular transmission is involved in the redilatation of the pupil following a miotic response to light stimulation.