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Bioavailability of the antiemetic metopimazine given as a microenema
Author(s) -
HERRSTEDT JØRN,
JØRGENSEN MORTEN,
ANGELO HELLE RIIS,
RASSING MARGRETHE RØMER,
MØLLERSONNERGAARD JØRN,
DOMBERNOWSKY PER
Publication year - 1996
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1996.35220.x
Subject(s) - bioavailability , antiemetic , metabolite , oral administration , pharmacokinetics , absorption (acoustics) , first pass effect , pharmacology , rectal administration , medicine , anesthesia , vomiting , physics , acoustics
The absorption of the antiemetic metopimazine (MPZ) given as a single dose of (a) 40 mg microenema, (b) 40 mg orally and (c) 10 mg as a 60 min i.v. continuous infusion was investigated in six healthy volunteers. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite were measured. The bioavailability of MPZ given orally and as enemas was 22.3 and 19.5% respectively. Partial avoidance of hepatic first pass metabolism was seen with the enemas, which in contrast to suppositories, seems to represent a reliable form of rectal administration.