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Intestinal absorption of strontium chloride in healthy volunteers: pharmacokinetics and reproducibility
Author(s) -
SIPS A. J. A. M.,
Van Der VIJGH W. J. F.,
BARTO R.,
NETELENBOS J. C.
Publication year - 1996
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1996.33411.x
Subject(s) - strontium , pharmacokinetics , bioavailability , strontium chloride , chemistry , absorption (acoustics) , volunteer , ingestion , meal , reproducibility , calcium , oral administration , chromatography , pharmacology , medicine , biochemistry , materials science , food science , biology , organic chemistry , composite material , agronomy
1 The absorption kinetics of orally administered strontium chloride and its reproducibility were investigated in healthy volunteers after administering strontium either under fasting conditions (study I, n =8) or in combination with a standardized meal (study II, n =8). Each subject received strontium orally at day 0, 14, and 28 and intravenously at day 42. The study was performed as part of a project in which a simple clinical test for measuring intestinal calcium absorption is being developed, based on the use of stable strontium as a marker. 2 Plasma strontium concentration–time curves were analysed by noncompartment analysis and a four compartment disposition model. Within a volunteer each oral curve was fitted simultaneously with the intravenous curve, by which means a two segment model for absorption was revealed. 3 Mean absolute bioavailability of strontium was 25% without a meal and 19% with a meal, whereas the intraindividual variation was 24% and 20%, respectively. 4 Various limited sampling absorption parameters were determined in order to select a potential test parameter for measuring intestinal calcium absorption using strontium as a marker. Fractional absorption at 4 h (Fc 240 ), obtained after co‐ingestion of strontium with a meal, appeared to be the best test parameter, because it represented bioavailability well ( r =0.90).