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Microsatellite markers associated with quantitative trait loci controlling antibody response to Escherichia coli and Salmonella enteritidis in young broilers
Author(s) -
Yunis R.,
Heller E. D.,
Hillel J.,
Cahaner A.
Publication year - 2002
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1046/j.1365-2052.2002.00890.x
Subject(s) - biology , salmonella enteritidis , sire , genetics , microsatellite , quantitative trait locus , escherichia coli , population , backcrossing , genetic marker , locus (genetics) , salmonella , gene , zoology , allele , bacteria , demography , sociology
A unique resource population was produced to facilitate detection of microsatellite markers associated with quantitative trait loci controlling antibody (Ab) response in broiler chickens. Three F 1 males were produced by mating two lines divergently selected on Ab response to Escherichia coli vaccination. Each F 1 male was mated with females from four genetic backgrounds: F 1 , high‐Ab line (HH), low‐Ab line and commercial line, producing three resource families, each with four progeny types. About 1700 chicks were immunized with E. coli and Salmonella enteritidis vaccines. Selective genotyping was conducted on the individuals with highest or lowest average Ab to E. coli and S. enteritidis within each progeny type in each sire family. Twelve markers were significantly associated with Ab to E. coli and six of them were also associated with Ab to S. enteritidis , mostly exhibiting a similar low effect (∼ 0.35 phenotypic SD) in all progeny types. Four markers exhibited a highly significant and much larger effect (∼1.7 SD), but only in progeny of females from the HH, suggesting that a backcross to the high parental line should be preferred over the commonly used F 2 population. Results from two markers suggested a quantitative trait locus on chromosome 2 around 400 cM. The marker MCW0083, significant in two sire families, is closely linked to the bone morphogenetic protein 2 ( BMP2 ) gene, known to be associated with the control of T‐cell transformation in humans.

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