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Characterization of the porcine FABGL gene
Author(s) -
Jacobs K.,
Mattheeuws M.,
Van Poucke M.,
Van Zeveren A.,
Peelman L. J.
Publication year - 2002
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1046/j.1365-2052.2002.00849.x
Subject(s) - biology , gene , genetics , coding region , major histocompatibility complex , microbiology and biotechnology , escherichia coli , peptide sequence
The porcine major histocompatibility complex, also called swine lymphocyte antigen (SLA) complex, is of particular interest not only because of its central role in the immune response, but also because of its influence on many traits such as reproduction, fatness and meat quality. The porcine FABGL (FabG (beta‐ketoacyl‐[acyl‐carrierprotein] reductase, Escherichia coli ) like) gene, coding for a 17 β ‐hydroxysteroid dehydrogenase (17 β ‐HSD), is a candidate gene for these traits. The complete gene was sequenced and compared with human and mouse FABGL sequences. The deduced amino acid sequence showed 85 and 83% sequence identity to human and mouse sequences, respectively. Polymorphicic Bbv I and Dde I restriction sites were found in the porcine FABGL gene. The promoter was compared with the promoter regions of human and mouse FABGL sequence in order to identify putative regulatory elements. The transcription profile of the porcine gene was determined and showed a widespread tissue distribution.