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The porcine sarcolipin (SLN) gene: identification of an SNP and linkage mapping to chromosome 9
Author(s) -
Fontanesi L.,
Davoli R.,
Milc J.,
Russo V.
Publication year - 2001
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1046/j.1365-2052.2001.0700c.x
Subject(s) - humanities , biology , library science , art , computer science
Sarcolipin (SLN) is a 31-amino acid proteolipid that regulates the activity of SERCA1 (ATP2A1), a fasttwitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase. Two alleles were identified by SSCP analysis in the 218 bp fragment of the porcine SLN gene. Mendelian segregation was confirmed in three-generation families of the PiGMaP Consortium. The DNA samples belonging to six threegeneration families of the PiGMaP Consortium were genotyped at the SLN locus obtaining 98 informative meiosis. Multipoint sex-averaged map of porcine chromosome 9, placed SLN between markers PPP2ARB and CRYAB (PPP2ARB± 24.7 cM ± SLN ± 3.1 cM ± CRYAB ±). This assignment confirms the physical mapping of the porcine SLN gene to chromosome9p24-(1/3p21) previously obtaine