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Chromosomal assignment of two putative canine keratin gene clusters
Author(s) -
Keller R. C.,
Switonski M.,
Jörg H.,
Ladon D.,
Arnold S.,
Schelling C.
Publication year - 1998
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1046/j.1365-2052.1998.00276.x
Subject(s) - biology , cosmid , keratin , keratin 6a , gene , genetics , gene cluster , microbiology and biotechnology , gene mapping , karyotype , chromosome , keratin 5 , x chromosome , intermediate filament , cytoskeleton , cell
Mutations in keratin genes account for a number of inherited keratodermas in humans. The groups of basic and acidic keratin genes are clustered on human chromosomes 12 and 17, respectively. The present authors have assigned the two putative keratin gene clusters to canine chromosomes using canine cosmid clones. Successful fluorescence in situ hybridization mapped the putative cluster of canine acidic genes to dog chromosome 20 and the putative cluster of basic keratin genes to a small autosome not yet included in the partial canine standard karyotype.