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A 5‐μm filter does not reduce propofol‐induced pain
Author(s) -
Hellier C.,
Newell S.,
Barry J.,
Brimacombe J.
Publication year - 2003
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2003.03191.x
Subject(s) - propofol , medicine , anesthesia , cannula , vial , surgery , lidocaine , chromatography , chemistry
Summary We assessed the effectiveness of a 5‐μm filter in reducing propofol‐induced pain and determined whether any reduction is due to removal of contaminants or an alteration in flow characteristics. A total of 120 unpremedicated women (ASA 1–3, aged 18–70 yr) were randomly allocated to one of three equal‐sized groups. In group A, propofol was drawn up and injected through an unfiltered plastic cannula. In group B, propofol was drawn up through a 5‐μm filter needle and injected through an unfiltered plastic cannula. In group C, propofol was drawn up and injected through a 5‐μm filter needle. Unmodified propofol from a 20‐ml rubber topped vial at room temperature was used. A 22‐g cannula was inserted into the largest visible vein on the dorsum of the non‐dominant hand. Propofol was administered at 0.5 ml.s −1 and patients were asked about pain every 10 s until unresponsive, by a blinded observer. The pain score for the patient was the taken as the most severe pain documented. The frequency and severity of pain were similar among groups. We conclude that a 5‐μm filter does not reduce pain associated with injection of propofol drawn from a vial with a rubber bung.