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The effect of prophylactic metaraminol on systemic hypotension caused by induction of anaesthesia with propofol in patients over 55 years old*
Author(s) -
Chiu C. L.,
Tew G. P.,
Wang C. Y.
Publication year - 2001
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2001.02059-4.x
Subject(s) - metaraminol , medicine , propofol , anesthesia , fentanyl , blood pressure , placebo , saline , general anaesthesia , alternative medicine , pathology
We conducted a double‐blind, randomised, placebo‐controlled study evaluating the efficacy of prophylactic metaraminol for preventing propofol‐induced hypotension. Thirty patients aged 55–75 years undergoing general anaesthesia were randomly allocated to receive either metaraminol 0.5 mg or saline before administration of fentanyl 1 µ g.kg −1 and propofol 2 mg.kg −1 . Induction of anaesthesia was associated with a decrease in mean and systolic arterial pressure in both groups (p = 0.0001). However, there was no significant difference between the two groups. These results show that prophylactic use of metaraminol 0.5 mg does not prevent the decrease in blood pressure following fentanyl and propofol induction in older patients.