Premium
A pharmacokinetic model for factor VIII dosing during active haemorrhage in patients with haemophilia A
Author(s) -
Ho A. M.H.,
Dion P.,
Karmakar M. K.,
Cheng G.,
Derrick J. L.,
Chung D. C.,
Tay B. A.
Publication year - 2001
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2001.02058-3.x
Subject(s) - medicine , haemophilia , dosing , pharmacokinetics , haemophilia a , compartment (ship) , plasma concentration , haemophilia b , anesthesia , blood loss , surgery , pharmacology , oceanography , geology
A theoretical one‐compartment pharmacokinetic model is described, the aim of which is to guide factor VIII replacement therapy in patients with haemophilia A suffering from significant and ongoing haemorrhage. Based on our calculations, plasma factor VIII concentrations can decrease at a rapid rate even with non‐severe blood loss.