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Kinin‐mediated anaphylactoid reaction implicated in acute intra‐operative pulseless electrical activity
Author(s) -
O'Sullivan S.,
McElwain J. P.,
Hogan T. S.
Publication year - 2001
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2001.01916-2.x
Subject(s) - medicine , epinephrine , kinin , anesthesia , anaphylactoid reactions , pulseless electrical activity , anaphylaxis , bradykinin , allergy , immunology , resuscitation , receptor , cardiopulmonary resuscitation
A 65‐year‐old patient undergoing total hip replacement under general anaesthesia suffered acute pulseless electrical activity with a fatal outcome. A kinin‐mediated analphylactoid reaction following administration of a polygeline plasma expander (Haemaccel®) was implicated by in vitro testing. This case report illustrates the diagnostic difficulties posed by non‐histaminoid anaphylactoid reactions and the resistance to epinephrine of kinin‐mediated hypotension.