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Randomised double‐blind comparison of ondansetron and droperidol to prevent postoperative nausea and vomiting associated with patient‐controlled analgesia
Author(s) -
Millo J.,
Siddons M.,
Innes R. J.,
Laurie P. S.
Publication year - 2001
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2001.01763-4.x
Subject(s) - ondansetron , medicine , droperidol , anesthesia , nausea , vomiting , postoperative nausea and vomiting , antiemetic , bolus (digestion) , regimen , analgesic , morphine , patient controlled analgesia , oxycodone , surgery , opioid , receptor
In a randomised, double‐blind trial, we compared the use of ondansetron and droperidol for the prevention of nausea and vomiting after total abdominal hysterectomy, during patient‐controlled analgesia with morphine. One hundred and forty‐two patients were randomly allocated to one of two groups. All patients received a standardised general anaesthetic and postoperative analgesic regimen. One group received ondansetron 4 mg at induction of anaesthesia, and ondansetron 0.13 mg with each 1‐mg bolus dose of morphine. The other group received droperidol 0.5 mg at induction and droperidol 0.05 mg per 1‐mg bolus dose of morphine. Results were available for 137 patients. During the first 24 h after surgery, prophylaxis was successful in 26 of 66 patients given ondansetron (39%) compared with 36 of 71 patients given droperidol (51%). This difference was not statistically significant (Chi‐squared = 1.766, p = 0.18). We conclude that in the regimens studied, ondansetron is not more effective than droperidol at preventing postoperative nausea and vomiting.