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Cardiovascular effects of intravenous propofol administered at two infusion rates: a transthoracic echocardiographic study
Author(s) -
Bilotta F.,
Fiorani L.,
La Rosa I.,
Spinelli F.,
Rosa G.
Publication year - 2001
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2001.01717-5.x
Subject(s) - medicine , propofol , preload , anesthesia , hemodynamics , afterload , heart rate , blood pressure , contractility , ejection fraction , mean arterial pressure , cardiology , heart failure
We assessed the haemodynamic changes after a propofol infusion at two rates in low‐risk unpremedicated patients (ASA I–II). To determine contractility changes and loading conditions, we measured the ejection fraction, end‐systolic quotient and fractional shortening on transthoracic echocardiograms. We studied 40 patients undergoing peripheral neurosurgical procedures under general anaesthesia induced by propofol alone (total dose 2.5 mg.kg −1 ). Patients were randomly assigned to receive propofol at an infusion rate of 10 mg.s −1 ; or 2 mg.s −1 . Haemodynamic data were recorded simultaneously immediately before propofol infusion, at the end of infusion, and 5 and 10 min after the infusion ended. The higher infusion rate induced a larger decrease in mean arterial pressure than the lower infusion rate (− 20% vs. − 10% from baseline, p = 0.01). In both groups, global and segmental ventricular function remained unchanged throughout the study. In both groups, there were markedly reduced end‐systolic quotients – presumably related to diminished afterload, and in the higher infusion‐rate group a significant reduction in fractional shortening – presumably related principally to diminished preload.