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Patient‐controlled analgesia and postoperative nausea and vomiting: efficacy of a continuous infusion of ondansetron
Author(s) -
White L. A.,
Vanarase M.,
Brockbank K.,
Barrett R. F.
Publication year - 2001
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2001.01708-5.x
Subject(s) - ondansetron , medicine , anesthesia , nausea , postoperative nausea and vomiting , vomiting , placebo , bolus (digestion) , patient controlled analgesia , surgery , morphine , alternative medicine , pathology
A continuous infusion of ondansetron was compared with a placebo infusion in 80 patients undergoing major breast reconstructive surgery. All patients received a standard anaesthetic and a bolus dose of ondansetron after induction. They were then randomly allocated to receive an intravenous infusion of ondansetron or a placebo infusion for 24 h in a double‐blind fashion. Postoperative analgesia was provided by patient‐controlled subcutaneous diamorphine. In the ondansetron group, the severity of nausea, measured by a 10‐point verbal rating scale, was reduced (p = 0.01) and fewer patients stated at postoperative interview that nausea and vomiting was a problem (p = 0.01).