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The effect of intravenous dexmedetomidine premedication on the dose requirement of propofol to induce loss of consciousness in patients receiving alfentanil
Author(s) -
Peden C. J.,
Cloote A. H.,
Stratford N.,
PrysRoberts C.
Publication year - 2001
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2001.01553.x
Subject(s) - dexmedetomidine , medicine , propofol , anesthesia , premedication , loading dose , alfentanil , adverse effect , sedation , pharmacology
Dexmedetomidine reduces the dose requirements for opioids and anaesthetic agents. We conducted a single‐centre, open‐label, noncomparative phase II study of the effect of intravenous dexmedetomidine on the dose requirement of propofol to induce loss of consciousness in 49 ASA I and II patients. The initial dexmedetomidine infusion scheme was reduced twice because of adverse events. Forty patients who received the final infusion scheme were randomly allocated to receive one of five stepped propofol infusions; loss of consciousness was assessed after 21 min. The ED 50 for the final infusion rate of propofol to suppress consciousness was 3.45 mg.kg −1 .h −1 (95% CL 2.7–4.2): ED 95 was 6.68 mg.kg −1 .h −1 (95% CL 5.1–19.1), EC 50 was 1.69 µ g.ml −1 (95% CL 0.95–2.5) and EC 95 was 5.7 µ g.ml −1 (95% CL 3.2 to > 10). Our final dose of dexmedetomidine of 0.63 µ g.kg −1 caused a reduction in the overall concentration and dose of propofol required to produce loss of consciousness, but no significant shift in the dose–response curve compared with other studies.