Premium
Setting targets for sedation with a target‐controlled propofol infusion
Author(s) -
Janzen P. R. M.,
Hall W. J.,
Hopkins P. M.
Publication year - 2000
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2000.01534.x
Subject(s) - medicine , propofol , sedation , target controlled infusion , anesthesia , intensive care medicine , remifentanil
We studied 30 unpremedicated patients undergoing muscle biopsy under femoral nerve block to determine sedation levels reached with a Diprifusor® target‐controlled propofol infusion, in order to establish the equivalent of the ED 50 for different levels of depth of sedation. Infusion was started at 0.8 µg.ml −1 and altered by increments of 0.1 µg.ml −1 after equilibrium between target and calculated concentrations, until the desired level of sedation was reached. The ED 50 target propofol concentrations for sedation at sedation levels 2 (drowsy), 3 (drowsy, responds to verbal stimulation) and 4 (responsive to physical stimulation only) were 1.0 µg.ml −1 , 1.6 µg.ml −1 and 2.1 µg.ml −1 , respectively. At sedation level 3, several patients exhibited spontaneous movement, hindering surgery. Oxygen supplementation is recommended for sedation at level 4.