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The effect of halothane and isoflurane on plasma cytokine levels
Author(s) -
Helmy S. A. K.,
AlAttiyah R. J.
Publication year - 2000
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2000.01472-2.x
Subject(s) - isoflurane , medicine , halothane , anesthesia , cytokine , general anaesthesia , surgery
The aim of this study was to investigate the effect of halothane vs. isoflurane on cytokine production during minor elective surgery. Forty adult patients, ASA I‐II were randomly allocated to receive halothane or isoflurane. Venous samples for interleukin (IL)‐1β, IL‐2, IL‐6, tumour necrosis factor‐α (TNF‐α) and interferon‐γ (IFN‐γ) were taken before anaesthesia, before incision, at the end of anaesthesia and 24 h postoperatively. In both groups, IL‐6 and TNF‐α levels remained low throughout the study period. Before incision, in both groups IL‐1β and IFN‐γ showed a decrease (p < 0.01 for IL‐1β in isoflurane group and p < 0.05 for the others) compared with pre‐induction. By the end of anaesthesia and surgery, IL‐1β had increased significantly (p < 0.05) and IFN‐γ had decreased significantly (p < 0.05) in both groups compared with pre‐incisional levels. By 24 h postoperatively in both groups, IL‐1β had decreased significantly (p < 0.05), whereas IFN‐γ had increased significantly (p < 0.05) compared with the end of anaesthesia and surgery level. Pre‐incisionally, IL‐2 increased in the halothane group (p < 0.01), whereas it decreased significantly in the isoflurane group (p < 0.001) compared with the pre‐induction level. By the end of anaesthesia and surgery and by 24 h postoperatively, IL‐2 had decreased significantly in the halothane group (p < 0.001), whereas it increased significantly in the isoflurane group (p < 0.001) compared with pre‐incision and end of anaesthesia and surgery levels, respectively.