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Early release pattern of S100 protein as a marker of brain damage after warm cardiopulmonary bypass
Author(s) -
Shaaban Ali M.,
Harmer M.,
Vaughan R. S.,
Dunne J.,
Latto I. P.
Publication year - 2000
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.2000.01330-1.x
Subject(s) - cardiopulmonary bypass , medicine , cardiology , s100 protein , anesthesia , coronary artery bypass surgery , artery , cardiac surgery , bypass surgery , immunohistochemistry
Warm blood cardioplegia may be more beneficial to the heart than cold cardioplegia, but the effects of warm cardiopulmonary bypass and warm blood cardioplegia on the brain are controversial. S100 protein is an early marker of brain damage and has been detected after cold cardiopulmonary bypass. We studied S100 concentrations in 20 patients undergoing coronary artery bypass surgery before and after warm cardiopulmonary bypass (34–37 °C) using warm blood cardioplegia (37 °C) for all patients. The peak level of S100 protein occurred immediately after warm cardiopulmonary bypass, then decreased progressively until the last measurement at 4.5 h after bypass. The peak level appears to be dependent upon the age of the patient, with the following regression equation: y = −3.2 + 0.08 x , where y is S100 protein concentration in µ g.l −1 and x is patient age in years. Further studies are needed to investigate the clinical significance of this early release pattern. Patient age should be taken into account when studying S100 protein levels after cardiopulmonary bypass.