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Ondansetron versus placebo for the control of nausea and vomiting during Caesarean section under spinal anaesthesia
Author(s) -
Abouleish E. I.,
Rashid S.,
Haque S.,
Giezentanner A.,
Joynton P.,
Chuang A. Z.
Publication year - 1999
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1999.00798.x
Subject(s) - ondansetron , medicine , nausea , anesthesia , vomiting , caesarean section , placebo , postoperative nausea and vomiting , saline , pregnancy , alternative medicine , pathology , biology , genetics
This prospective, randomised, placebo‐controlled, double‐blind study was performed to evaluate the effects of ondansetron on nausea and vomiting during elective Caesarean section under spinal anaesthesia. Seventy‐four full‐term parturients were studied. After umbilical‐cord clamping, ondansetron 4 mg or 0.9% saline was injected intravenously and the study period continued for 2 h. The severity of nausea was graded from 0 = none to 10 = maximum, while that of vomiting was graded from single = once per min to continuous = multiple per min. The incidence of vomiting was lower following ondansetron (36%) compared with the control group (58%, p < 0.028). Neither the severity of vomiting nor the incidence of nausea was influenced by ondansetron. However, for those who experienced nausea, ondansetron reduced its severity (p = 0.05). We conclude that the intra‐operative administration of 4 mg ondansetron intravenously during Caesarean section under spinal anaesthesia significantly reduces the incidence of vomiting and the severity of nausea.