Premium
Effects of nitrous oxide on haemodynamic and electroencephalographic responses induced by tetanic electrical stimulation during propofol anaesthesia
Author(s) -
Inada T.,
Shingu K.,
Nakao S.,
Nagata A.
Publication year - 1999
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1999.00752.x
Subject(s) - propofol , anesthesia , medicine , tetanic stimulation , nitrous oxide , stimulation , heart rate , hemodynamics , blood pressure , noxious stimulus , nociception , inhibitory postsynaptic potential , receptor , excitatory postsynaptic potential
We studied the effect of nitrous oxide on haemodynamic and electroencephalographic responses caused by noxious stimulation during propofol anaesthesia. Thirty‐four patients (ASA I–II) were anaesthetised with propofol 3 mgkg −1 and were randomly allocated to receive either 60% nitrous oxide in oxygen or 40% oxygen in air. Anaesthesia was maintained using propofol infusion of 10 mgkg −1 .h −1 for the first 10 min, 8 mgkg −1 .h −1 for the next 10 min and 6 mgkg −1 .h −1 thereafter. Thirty minutes after the induction of anaesthesia, tetanic electrical stimulation (80 mA, 100 Hz) was applied to the ulnar nerve. Tetanic stimulation significantly increased blood pressure and heart rate in both groups (p < 0.005 or less), but did not induce any arousal pattern on the electroencephalograph. Nitrous oxide significantly attenuated the tetanic stimulation‐induced increase in blood pressure (p < 0.05 or less), but not the heart rate.