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A comparison of the effects of dopexamine and prostacyclin in systemic inflammatory response syndrome
Author(s) -
Blunt M.,
Young P.,
Ridley S.
Publication year - 1999
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1999.00748.x
Subject(s) - medicine , prostacyclin , perfusion , anesthesia , splanchnic , urine , washout , hemodynamics
Forty critically ill patients fulfilling the definitions of systemic inflammatory response syndrome were enrolled in a double‐blind cross‐over interventional study assessing the effects of dopexamine and prostacyclin on splanchnic perfusion, cardiovascular function and oxygen flux. The cross‐over design involved either dopexamine (1.25 μg.kg −1 .min −1 ) or prostacyclin (0.5 ng.kg −1 .min −1 ) being infused for 6 h followed by a 12‐h washout period prior to an identical infusion sequence using the other agent. Preliminary analysis revealed a significant period effect, so data from the second infusion period were excluded from further analysis. Dopexamine caused a significant increase in heart rate (116 vs. 106 beat.min −1 ), and urine output (103 vs. 69 ml.h −1 ). Dopexamine produced a significant increase in oxygen delivery (infusion 548 ml O 2 .min −1 .m −2 ; no infusion 492 ml O 2 .min −1 .m −2 ) while prostacyclin caused a decrease (infusion 460 ml O 2 .min −1 .m −2 ; no infusion 547 ml O 2 .min −1 .m −2 ). The results indicate that dopexamine improves oxygen delivery and urine output more effectively than prostacyclin.