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The effect of intrathecal magnesium sulphate on nociception in rat acute pain models
Author(s) -
Ishizaki K.,
Sasaki M.,
Karasawa S.,
Obata H.,
Nara T.,
Goto F.
Publication year - 1999
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1999.00741.x
Subject(s) - medicine , nociception , magnesium , saline , anesthesia , intrathecal , paralysis , acute pain , analgesic , surgery , receptor , materials science , metallurgy
We examined the antinociceptive effect of intrathecally administered magnesium sulphate (MgSO 4 ) in rats, using acute pain models including mechanical pressure, heat and subcutaneous formalin injection. According to the locomotion test 10 μl of 6.2% MgSO 4 did not produce motor paralysis. At the same dose, responses to pressure and heat were intact, compared with controls given saline. MgSO 4 produced depression of pain responses only after the first 10 min in the formalin test. Our studies indicated that MgSO 4 did not show remarkable antinociceptive effects in acute pain models.