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Effects of low‐dose isoflurane on saccadic eye movement generation[Note 1. This work was presented to the Anaesthetic Research Society, ...]
Author(s) -
Khan O.,
Taylor S. J.,
Jones J. G.,
Swart M.,
Hanes D. P.,
Carpenter R. H. S.
Publication year - 1999
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1999.00701.x
Subject(s) - saccadic masking , latency (audio) , isoflurane , medicine , eye movement , anesthesia , audiology , task (project management) , neuroscience , ophthalmology , psychology , computer science , telecommunications , management , economics
The effects of 0.15% quasi‐steady‐state end‐tidal isoflurane on two saccadic eye‐movement tests were examined in five volunteers using a newly devised computer‐based recording system. The tests were saccadic latency and a countermanding task, the latter being an indicator of the highest levels of conscious performance. A moving light‐emitting diode target was displayed on a screen and in the saccadic‐latency task the latency of eye movement to the target was measured. In all five subjects the latency increased with anaesthetic by an amount which varied from 8 to 45 ms. This result was significantly different (p < 0.05) from subjects without anaesthetic. In the countermanding task, the subject had to voluntarily inhibit movement to the target. Again anaesthetic increased the latency of response, which varied from 6 to 33 ms. This result was significantly different (p < 0.05) from subjects without anaesthetic. In these studies it appeared that two tasks, one a simple latency test and the other, the countermanding task, requiring higher cortical processing were equally impaired at subanaesthetic concentrations of isoflurane.