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Effective time to satisfactory intubation conditions after administration of rocuronium in adultsComparison of propofol and thiopentone for rapid sequence induction of anaesthesia
Author(s) -
Dobson A. P.,
McCluskey A.,
Meakin G.,
Baker R. D.
Publication year - 1999
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1999.00655.x
Subject(s) - rocuronium , medicine , propofol , anesthesia , intubation , rapid sequence induction , tracheal intubation , general anaesthesia
We determined the effective time to satisfactory intubation conditions after the administration of rocuronium 0.6 mgkg −1 to 120 unpremedicated adult patients anaesthetised with propofol 2.5 mgkg −1 or thiopentone 5 mgkg −1 . Intubation conditions were assessed in 10 subgroups of 12 patients at 30, 40, 50, 60 and 70 s. The effective times to satisfactory intubation conditions in 50 and 90% of patients were obtained by the method of maximum likelihood after log time–probit response transformations. Intubation conditions after induction of anaesthesia with propofol were satisfactory in 5/12 patients at 30 s, 7/12 at 40 s, 10/12 at 50 s, 11/12 at 60 s and 11/12 at 70 s compared with 1/12 patients at 30 s, 2/12 at 40 s, 5/12 at 50 s, 7/12 at 60 s and 8/12 at 70 s after induction with thiopentone. The effective times to satisfactory intubation conditions in 50% and 90% (95% confidence intervals) of patients after rocuronium 0.6 mgkg −1 were 34 (26–40) s and 61 (50–81) s in patients given propofol compared with 57 (48–69) s and 101 (79–167) s in patients given thiopentone. We conclude that rocuronium 0.6 mgkg −1 may be a suitable alternative to suxamethonium during rapid sequence induction of anaesthesia with propofol in situations where suxamethonium is contraindicated.