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Evaluation of remifentanil for control of haemodynamic response to tracheal intubation
Author(s) -
McAtamney D.,
O'Hare R.,
Hughes D.,
Carabine U.,
Mirakhur R.
Publication year - 1998
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1998.00601.x
Subject(s) - medicine , remifentanil , rocuronium , anesthesia , tracheal intubation , laryngoscopy , intubation , heart rate , bolus (digestion) , hemodynamics , blood pressure , haemodynamic response , saline , mean arterial pressure , elective surgery , propofol , surgery
We have studied the effect of three bolus doses of remifentanil on the haemodynamic response to laryngoscopy and tracheal intubation. Using a double‐blind design, 80 ASA 1 or 2 patients presenting for elective surgery received saline placebo or remifentanil 0.25, 0.5 or 1.0 μg.kg −1 by random allocation. Anaesthesia was induced with thiopentone 5–7 mg.kg −1 and followed immediately by the study medication given as a bolus over 30 s. Muscle relaxation was provided with rocuronium 0.75 mg.kg −1 . The patients' tracheas were intubated under direct laryngoscopy 1 min later. Noninvasive arterial blood pressure and heart rate were recorded immediately before induction of anaesthesia and then at intervals until 5 min after tracheal intubation. There was a significant increase in heart rate (p < 0.01) and systolic arterial pressure (p < 0.01) in all groups after tracheal intubation. However, this was short‐lived and of a smaller magnitude in the remifentanil 1 μg.kg −1 group in which the increase was significantly lower than in the control group (p < 0.01).