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Systemic mastocytosis presenting as profound cardiovascular collapse during anaesthesia
Author(s) -
Vaughan S. T. A.,
Jones G. N.
Publication year - 1998
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1998.00536.x
Subject(s) - medicine , bronchospasm , histamine , systemic mastocytosis , anesthesia , anaphylaxis , anaphylactic shock , mast cell , general anaesthesia , shock (circulatory) , allergy , immunology , asthma
Mastocytosis is a rare disorder with serious anaesthetic implications. Anaesthetic management is hazardous since trauma, stress, extremes of temperature and drugs may precipitate intra‐operative mast cell degranulation. Release of histamine and other mast cell mediators can lead to profound cardiovascular collapse and even death. We present a case report of a patient with mastocytosis who suffered cardiac arrest during anaesthesia. Anaphylactoid/anaphylactic shock may be delayed and lack supporting signs of histamine release such as cutaneous flushing and bronchospasm.