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The uptake of sevoflurane during anaesthesia
Author(s) -
Vagts D. A.,
Lockwood G. G.
Publication year - 1998
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1998.00487.x
Subject(s) - sevoflurane , medicine , desflurane , anesthesia
The rate of uptake of sevoflurane during clinical anaesthesia (1.3 MAC) was measured by computer‐controlled injection of liquid anaesthetic into a closed breathing system. The cumulative uptake of sevoflurane was 4.8 ml, 7.4 ml. 9.5 ml and 11.5 ml at 30, 60, 90 and 120 min, respectively. The ratio of inspired to end‐expired sevoflurane was greater than similar measurements we have made for desflurane in the past, but the absolute rate of sevoflurane uptake was less than the rate of uptake of desflurane in these cases. The rate of uptake was equivalent to 0.59e −0.32 t + 0.039e −0.036 t + 0.105e −0.0034 t mlmin −1 liquid sevoflurane. Plasma urea and creatinine measured on the first postoperative day were not significantly different from pre‐operative values.