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Closed‐loop controlled administration of propofol using bispectral analysis
Author(s) -
Mortier E.,
Struys M.,
De Smet T.,
Versichelen L.,
Rolly G.
Publication year - 1998
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1998.00467.x
Subject(s) - propofol , bispectral index , medicine , anesthesia , closed loop , controller (irrigation) , control engineering , agronomy , engineering , biology
Ten patients, undergoing elective orthopaedic surgery under spinal anaesthesia, were sedated with propofol using a closed‐loop feedback control system. The bispectral index (BIS), a new processed EEG parameter, was used as control variable. Propofol administration was controlled by a patient individualised adaptive model‐based controller incorporating target‐controlled infusion technology combined with a pharmacokinetic‐dynamic model. This feedback control system for propofol administration proved to be adequate and safe. BIS was found to be well suited as control variable.