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Health‐related quality of life in functional dyspepsia
Author(s) -
ElSerag H. B.,
Talley N. J.
Publication year - 2003
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2003.01706.x
Subject(s) - medicine , quality of life (healthcare) , health related quality of life , population , sf 36 , physical therapy , disease , nursing , environmental health
Summary Background : We performed a systematic review of the literature to compare the health‐related quality of life (HRQOL) of patients with functional dyspepsia with either healthy controls or those with other diseases. Methods : Full‐length published manuscripts during 1980–2002 were included if (a) patients had functional dyspepsia, but not uninvestigated dyspepsia; and (b) HRQOL was measured using a validated generic or dyspepsia‐specific instruments, but not global assessment alone. Results : Twelve studies were reviewed; six fulfilled the selection criteria. None examined HRQOL among samples of the general population. None used dyspepsia‐specific HRQOL instruments. Three studies contained four comparisons of HRQOL between functional dyspepsia patients and controls; two studies examined HRQOL changes in response to therapy. Two studies demonstrated a significant reduction at least in some domains of HRQOL among patients with functional dyspepsia compared to controls, while one study was negative. In general, studies that reported a decline in HRQOL Short Form‐36 (SF‐36) showed that changes in the physical domain were similar to those on mental domain of the SF‐36. Conclusions : There is some evidence for a decrease in HRQOL in patients with moderate to severe functional dyspepsia who seek care for their symptoms; however, more studies are needed. A therapeutic response in functional dyspepsia‐related pain or discomfort might result in a corresponding improvement in HRQOL.