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Favourable effect of regular intake of fermented milk containing Lactobacillus johnsonii on Helicobacter pylori associated gastritis
Author(s) -
Pantoflickova D.,
CorthésyTheulaz I.,
Dorta G.,
Stolte M.,
Isler P.,
Rochat F.,
Enslen M.,
Blum A. L.
Publication year - 2003
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2003.01675.x
Subject(s) - helicobacter pylori , gastritis , antrum , gastroenterology , medicine , placebo , ingestion , mucus , spirillaceae , antibiotics , stomach , microbiology and biotechnology , biology , pathology , alternative medicine , ecology
Summary Background : Lactobacillus johnsonii (Lj1) had an in vitro and in vivo inhibitory effect on Helicobacter pylori . Fermented milk containing Lj1 (LC 1 ), coadministered with antibiotics had a favourable effect on H. pylori gastritis. Aim : Evaluate the effect of LC 1 intake without antibiotics on H. pylori gastritis. Methods : Fifty H. pylori positive healthy volunteers were randomised in a double‐blind study to LC 1 or placebo. Gastric biopsies from the antrum and corpus were obtained before, and after 3 and 16 weeks of treatment, for histology and quantitative cultures. Results : Severity and activity of antral gastritis was reduced after 16‐week LC 1 intake (pretreatment and 16‐week inflammatory cell score: 6.0 ± 0.8 vs. 5.3 ± 0.1; P = 0.04). H. pylori density decreased in the antrum after LC 1 intake (3‐week: 4.4 ± 0.6; 16‐week: 4.3 ± 0.5 log 10 colony forming units (cfu) vs. pretreatment 4.5 ± 0.4 log 10 cfu; P = 0.04, respectively). Mucus thickness increased after 16 weeks of LC 1 consumption (change of mucus thickness with LC 1 and placebo in the antrum: 0.6 ± 1.3 vs. ‐0.2 ± 1.0, P = 0.01; in the corpus: 0.3 ± 1.1 vs. ‐0.6 ± 1.5, P = 0.03). Conclusion : LC 1 intake had a favourable, albeit weak, effect on H. pylori associated gastritis, particularly in the antrum. Regular ingestion of fermented milk containing L. johnsonii may reduce the risk of developing disorders associated with high degrees of gastric inflammation and mucus depletion.