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A rapid‐release 50‐mg tablet‐based 13 C‐urea breath test for the diagnosis of Helicobacter pylori infection
Author(s) -
Wong W. M.,
Lam S. K.,
Lai K. C.,
Chu K. M.,
Xia H. H. X.,
Wong K. W.,
Cheung K. L.,
Lin S. K.,
Wong B. C. Y.
Publication year - 2003
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2003.01417.x
Subject(s) - medicine , breath test , urea , helicobacter pylori , urease , urea breath test , gastroenterology , rapid urease test , gold standard (test) , population , helicobacter pylori infection , chemistry , environmental health , organic chemistry
Summary Background : Recently, a rapid‐release 100‐mg 13 C‐urea tablet with citrate supplement (Diabact UBT) showed excellent performance in a European population. Aim : To investigate the accuracy of a 50‐mg tablet‐based 13 C‐urea breath test protocol. Methods : Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13 C‐Urea breath test was performed using a 50‐mg 13 C‐urea tablet (Diabact UBT) and compared with the gold standard (rapid urease test and histology). Baseline, 10‐min, 20‐min and 30‐min breath samples were collected in all cases. The cut‐off values at each measurement interval were determined by three standard deviations above the mean excess δ 13 CO 2 excretion of Helicobacter pylori ‐negative patients. Results : Two hundred patients (150 before therapy and 50 after therapy) were available for analysis, with a mean age of 48.4 years, and 99 patients (50%) were H. pylori positive. The sensitivity and specificity of the 50‐mg tablet‐based 13 C‐urea breath test at 10 min, 20 min and 30 min were 100% and 98%, 100% and 100%, and 100% and 98%, respectively. Conclusion : A 20‐min, 50‐mg tablet‐based 13 C‐urea breath test (Diabact UBT) protocol is highly accurate for the diagnosis of H. pylori infection.