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Osteoporosis in inflammatory bowel disease: effect of calcium and vitamin D with or without fluoride
Author(s) -
Abitbol V.,
Mary J. Y.,
Roux C.,
Soulé J. C.,
Belaiche J.,
Dupas J. L.,
Gendre J. P.,
Lerebours E.,
Chaussade S.
Publication year - 2002
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2002.01247.x
Subject(s) - medicine , osteoporosis , inflammatory bowel disease , vitamin d and neurology , bone mineral , placebo , calcium , fluoride , bone density , bone disease , vitamin , gastroenterology , vitamin d deficiency , endocrinology , disease , pathology , chemistry , inorganic chemistry , alternative medicine
Background: Previous data have indicated low bone formation as a mechanism of osteoporosis in inflammatory bowel disease. Fluoride can stimulate bone formation. Aim: To assess the effect of fluoride supplementation on lumbar spine bone mineral density in osteoporotic patients with inflammatory bowel disease treated in parallel with calcium and vitamin D. Methods: In this prospective, randomized, double‐blind, parallel and placebo‐controlled study, 94 patients with inflammatory bowel disease (lumbar spine T score below − 2 standard deviations, normal serum 25OH vitamin D), with a median age of 35 years, were included. Bone mineral density was measured by dual‐energy X‐ray absorptiometry. Patients were randomized to receive daily either sodium monofluorophosphate (150 mg, n =45) or placebo ( n =49) for 1 year, and all received calcium (1 g) and vitamin D (800 IU). The relative change in bone mineral density from 0 to 12 months was tested in each group (fluoride or placebo) and compared between the groups. Results: Lumbar spine bone mineral density increased significantly in both groups after 1 year: 4.8 ± 5.6% ( n =29) and 3.2 ± 3.8% ( n =31) in the calcium–vitamin D–fluoride and calcium–vitamin D–placebo groups, respectively ( P < 0.001 for each group). There was no difference between the groups ( P =0.403). Similar results were observed according to corticosteroid intake or disease activity. Conclusions: Calcium and vitamin D seem to increase lumbar spine density in osteoporotic patients with inflammatory bowel disease; fluoride does not provide further benefit.