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Does intravenous ondansetron affect gastric emptying of a solid meal, gastric electrical activity or blood hormone levels in healthy volunteers?
Author(s) -
Netzer P.,
Gaia C.,
Lourens S. T.,
Reber P.,
Wildi S.,
Noelpp U.,
Ritter E. P.,
Ledermann H.,
Lüscher D.,
Varga L.,
Kinser J. A.,
Büchler M. W.,
Scheurer U.
Publication year - 2002
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2002.01152.x
Subject(s) - motilin , gastric emptying , ondansetron , medicine , endocrinology , crossover study , vasoactive intestinal peptide , gastrointestinal hormone , placebo , gastroparesis , cholecystokinin , vomiting , gastroenterology , stomach , hormone , peptide hormone , neuropeptide , receptor , alternative medicine , pathology
Background: In previous studies, tropisetron has been shown to accelerate gastric emptying of a solid meal. However, it is uncertain whether other specific 5‐hydroxytryptamine‐3 receptor antagonists, such as ondansetron, also have a gastroprokinetic effect in humans. Aim: To evaluate the effect of ondansetron on gastric half‐emptying time ( T 1/2 ) of a solid meal, gastric myoelectrical activity and hormone levels in 14 healthy volunteers. Methods: In a placebo‐controlled, randomized, crossover study, we investigated the effects of ondansetron (8 mg intravenously) on the gastric emptying of solids (by scintigraphy), gastric myoelectrical activity (by electrogastrography) and the post‐prandial release of cholecystokinin, gastrin, human pancreatic polypeptide, gastric inhibitory polypeptide, vasoactive intestinal polypeptide, motilin, substance P and galanin. Results: The average T 1/2 values were 86 min and 85.5 min without lag time ( P =0.082) and 92 min and 93 min with lag time ( P =0.158) for the placebo and ondansetron treatments, respectively. The average T 1/2 of female volunteers was significantly longer than that of male volunteers. The dominant gastric electrical frequency and hormone plasma concentrations were not altered by ondansetron. Conclusions: Ondansetron did not affect the gastric emptying of solids, the dominant gastric electrical frequency or the plasma concentrations of the analysed gastrointestinal peptides.