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Non‐surgical treatment of hepatocellular carcinoma
Author(s) -
Alsowmely A. M.,
Hodgson H. J. F.
Publication year - 2002
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2002.01149.x
Subject(s) - medicine , hepatocellular carcinoma , cirrhosis , chemotherapy , liver transplantation , surgical resection , embolization , oncology , surgery , transplantation
Primary hepatocellular cancer is a disease with a poor prognosis for which there is little consensus on treatment and a paucity of comparative trials. The coexistence of cancer with cirrhosis complicates treatment, and also confers a high risk for the development of further tumours. Surgery, either by hepatic resection or orthotopic liver transplantation, is only a feasible option in a minority of patients. This article surveys the non‐surgical approaches to the treatment of hepatocellular cancers—local ablation techniques, arterial embolization with and without chemotherapy, conventional chemotherapy and hormonal modulation, and targeted and external irradiation.