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Twenty‐minute 50 mg 13 C‐urea breath test without test meal for the diagnosis of Helicobacter pylori infection in Chinese
Author(s) -
Wong W. M.,
Wong B. C. Y.,
Li T. M.,
Wong K. W.,
Cheung K. L.,
Fung F. M. Y.,
Xia H. H. X.,
Lam S. K.
Publication year - 2001
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2001.01078.x
Subject(s) - urea , breath test , medicine , urease , urea breath test , gastroenterology , rapid urease test , helicobacter pylori , meal , helicobacter pylori infection , chemistry , biochemistry
Background: We have previously shown that the 75 mg 13 C‐urea breath test without citrate test meal is highly accurate for the diagnosis of Helicobacter pylori infection in Chinese subjects. A lower dose 50 mg 13 C‐urea breath test protocol with a sampling time at 20 min has not been validated previously. Aim: To investigate the accuracy of a 20‐min 50 mg 13 C‐urea breath test protocol in Chinese subjects. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13 C‐urea breath test was performed using (a) 75 mg and 50 mg of 13 C‐urea on two separate days without a test meal, and (b) 50 mg of 13 C‐urea with 2.4 g citrate as test meal, and compared with the gold standard [rapid urease test (CLO test) and histology]. Baseline, 20‐min and 30‐min breath samples were collected in all cases. Results: Two hundred and six patients were tested. The accuracy of the 50 mg 13 C‐urea breath test (no citrate) at 20 min and 30 min was 98%, comparable to that of the 50 mg 13 C‐urea breath test with citrate (99.1%) and the 75 mg 13 C‐urea breath test without citrate (100%). Conclusions: A 20‐min 50 mg 13 C‐urea breath test without citrate produced highly accurate results for the diagnosis of Helicobacter pylori infection and is more economical and convenient for the Chinese population.