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Lansoprazole in children: pharmacokinetics and efficacy in reflux oesophagitis
Author(s) -
Faure C.,
Michaud L.,
Khan Shaghaghi E.,
Popon M.,
Laurence M.,
Mougenot J. F.,
Hankard R.,
Navarro J.,
JacqzAigrain E.
Publication year - 2001
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2001.01076.x
Subject(s) - lansoprazole , medicine , pharmacokinetics , proton pump inhibitor , discontinuation , gastroenterology , reflux , adverse effect , area under the curve , area under curve , omeprazole , disease
Background: Data on the proton pump inhibitor lansoprazole in paediatric patients are limited. Aim: To investigate the pharmacokinetics, optimal dosage and efficacy of lansoprazole in paediatric patients. Methods: A 24‐h gastric pH recording and a pharmacokinetic study were performed after 7 days of lansoprazole, 17 mg/m 2 , in 23 patients with reflux oesophagitis (median age, 3.5 years). Response was defined as pH > 3 for > 65% of the recording. The dosage was doubled in non‐responders. Patients with no response on day 14 were excluded. Responders underwent endoscopy after 4 weeks on the response‐inducing dosage; abnormal findings led to a repeat endoscopy after four additional weeks. Results: Nine patients responded to 17 mg/m 2 and six to 30.3 mg/m 2 . On day 7, time with pH > 3 was significantly correlated with the area under the plasma concentration–time curve ( P =0.003). The area under the plasma concentration–time curve was significantly greater in the nine responders to 17 mg/m 2 than in the 14 other patients. Pharmacokinetic parameters were similar in responders and non‐responders to the higher dose. After 4 weeks, oesophagitis was healed in 80% of responders. Adverse events occurred in three patients and required treatment discontinuation in one. Conclusions: Lansoprazole is effective and safe in children. The optimal starting dosage is 30 mg/m 2 or 1.4 mg/kg.