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Increased gastric acid secretion after Helicobacter pylori eradication may be a factor for developing reflux oesophagitis
Author(s) -
Koike T.,
Ohara S.,
Sekine H.,
Iijima K.,
Kato K.,
Toyota T.,
Shimosegawa T.
Publication year - 2001
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2001.00988.x
Subject(s) - hiatal hernia , medicine , gastroenterology , helicobacter pylori , reflux , gastric acid , gastrin , esophagitis , omeprazole , secretion , endoscopy , hernia , surgery , disease
Background: The role of acid secretion in reflux oesophagitis which may develop after H. pylori eradication is not well known. Aim: To investigate the participation of altered gastric acid secretion and the presence of hiatal hernia in the development of reflux oesophagitis after eradication therapy for H. pylori . Subjects and Methods: A total of 105 patients with H. pylori infection, but without reflux oesophagitis at the time of eradication therapy, were followed prospectively for 7 months after the clearance of this microorganism. Gastric acid secretion was assessed by endoscopic gastrin test, and the presence of hiatal hernia by endoscopy. Results: Reflux oesophagitis developed in 11 out of 105 (10.5%) patients when examined at 7 months after the eradication therapy. The incidence was correlated significantly with the increase in gastric acid secretion after the eradication of H. pylori , and was significantly higher in the patients with hiatal hernia (20%) than in those without it (0%). Conclusions: Increased acid secretion after H. pylori eradication is an important risk factor of reflux oesophagitis, especially in patients with hiatal hernia.