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Review article: healing after inflammatory injury – coordination of a regulatory peptide network
Author(s) -
Podolsky D. K.
Publication year - 2000
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2000.014s1087.x
Subject(s) - autocrine signalling , paracrine signalling , lamina propria , cytokine , epithelium , receptor , intestinal epithelium , medicine , microbiology and biotechnology , immunology , biology , neuroscience , pathology
Summary Intestinal epithelial cells are capable of producing a variety of cytokines and other regulatory factors that can affect functional regulation of the epithelium itself, through autocrine and paracrine mechanisms, as well as functional integration with lamina propria populations. The bi‐directional nature of this cytokine network is now apparent, with the demonstration that both rat and human intestinal epithelium‐derived cell lines possess a much greater array of cytokine receptors than previously anticipated.