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Is autonomic dysfunction a necessary condition for chronic peptic ulcer formation?
Author(s) -
Nomura M.,
Yukinaka M.,
Miyajima H.,
Nada T.,
Kondo Y.,
Okahisa T.,
Shibata H.,
Okamura S.,
Honda H.,
Shimizu I.,
Saito K.,
Oki T.,
Nakaya Y.,
Ito S.
Publication year - 2000
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2000.014s1082.x
Subject(s) - medicine , autonomic nervous system , helicobacter pylori , gastroenterology , peptic ulcer , heart rate variability , autonomic nerve , heart rate , peptic , cardiology , blood pressure
Summary Background : The relationship between 1/ f fluctuation of the heart rate variability and Helicobacter pylori infection was evaluated, in order to clarify whether autonomic nervous dysfunction is a necessary condition for chronic peptic ulcer formation. Methods : The subjects were 11 patients with recurrent chronic peptic ulcer and 20 age‐matched normal subjects. Holter ECGs were recorded over 24 h, and the 1/ f – x fluctuation of the heart rate was computed. The 1/ f – x fluctuation of the heart rate is a novel index of autonomic function that has been shown to reflect a patient's pleasant mood. For 1/ f – x fluctuation, the slope of the regression line (– x ) was determined and cosine fitting of the absolute slope of the regression line over a 24‐h period was performed. Results : For the normal group, the absolute slope of the regression line during daytime and night‐time were 0.53 ± 0.16 and 1.05 ± 0.18, respectively. For the peptic ulcer group, the corresponding values during daytime and night‐time were 0.94 ± 0.15 and 1.84 ± 0.18, respectively. The mean value of the cosine curve was 0.76 ± 0.23 in the normal group and 1.12 ± 0.25 in the peptic ulcer group. Thus, these values were significantly higher for the latter group than for the former group ( P < 0.05). No statistically significant difference in H. pylori infection between the two groups was observed. Conclusions : Autonomic nervous dysfunction as well as H. pylori infection appears to be a necessary condition for chronic peptic ulcer formation.