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A double‐blind, randomized, dose response study testing the pharmacological efficacy of synthetic porcine secretin
Author(s) -
Jowell P. S.,
RobuckMangum G.,
Mergener K.,
Branch M. S.,
Purich E. D.,
Fein S. H.
Publication year - 2000
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2000.00881.x
Subject(s) - secretin , medicine , bicarbonate , crossover study , adverse effect , volunteer , dosing , pharmacology , pancreas , biology , pathology , alternative medicine , agronomy , placebo
Background: Biologically derived porcine secretin has been used as a diagnostic agent in clinical gastrointestinal practice for many years. Pure synthetic porcine secretin is now available for investigational clinical use. Aim: To compare the pharmacology of synthetic porcine secretin and biologically derived porcine secretin in healthy volunteers. Methods: Secretin stimulation tests were performed in 12 volunteer subjects in a double‐blind, randomized, Latin square crossover design study comparing three doses of synthetic porcine secretin (0.05, 0.2, and 0.4 μg/kg) with a standard dose of biologically derived porcine secretin (1 CU/kg). Duodenal aspirates were analysed for total volume and for bicarbonate concentration. Total bicarbonate output was calculated. Results: Twelve subjects completed four dosing regimens. A multiple comparison test was used to compare dosing regimens. The 0.2 and 0.4 μg/kg doses of synthetic porcine secretin were not different from the 1 CU/kg dose of biologically derived porcine secretin for volume, bicarbonate concentration and total output from 0 to 60 min. Only one patient had an adverse event, which was mild, transient flushing after the 0.2 and 0.4 μg/kg doses of synthetic porcine secretin and after the 1 CU/kg dose of biologically derived porcine secretin. Conclusions: Synthetic porcine secretin has identical pharmacologic effects to biologically derived porcine secretin in normal subjects. Both drugs were safe and well‐tolerated. This study validates synthetic porcine secretin as a substitute for biologically derived porcine secretin.